Who Can Safely Use Mounjaro for Weight Loss?

Comedian Aishwarya Mohanraj recently revealed that she lost 22 kg over six months using the drug Mounjaro, sparking widespread discussion about GLP-1 weight loss medications.

In a YouTube video, she shared that her weight dropped from 74 kg to 52 kg. However, she also spoke about side effects such as nausea, discomfort and hair loss, highlighting that the journey was not easy.

Following the discussion, Dr Manoj Bharucha, consultant in gastrointestinal surgery at PD Hinduja Hospital and Medical Research Center, Khar, explained that such medications are not cosmetic solutions but serious medical treatments.

Not a “Beauty Treatment”

According to Dr Bharucha, drugs like Mounjaro are powerful metabolic medications that require strict medical supervision.

He stressed that these are not shortcuts for aesthetic weight loss. Instead, they are designed to manage chronic metabolic conditions.

Mounjaro is primarily approved for type 2 diabetes management. The obesity-focused version of the drug is marketed as Zepbound, while Wegovy is approved specifically for chronic weight management.

Who Is Eligible?

Eligibility is based on clinical health parameters, not clothing size or appearance.

Doctors generally consider the following criteria:

• Body Mass Index (BMI) of 30 or above (clinical obesity).

• BMI of 27 or above with weight-related conditions such as type 2 diabetes, hypertension or PCOS.

For South Asian populations, lower BMI thresholds may be considered. Experts note that this group tends to develop visceral fat and insulin resistance at lower body weights compared to some other populations.

Long-Term Commitment

GLP-1 medications are often described as a middle path between lifestyle changes and bariatric surgery. They can lead to 20–22% weight reduction in some cases.

However, doctors warn that many patients may need long-term or even lifelong use to maintain results.

When Should These Drugs Be Avoided?

Dr Bharucha cautioned that these medications should never be self-prescribed.

They are strictly contraindicated in:

• Pregnancy

• Individuals with a history of pancreatitis

• Those with a history of medullary thyroid cancer

He emphasised that proper medical consultation, monitoring and follow-up are essential to ensure safety and effectiveness.

The Bigger Conversation

The renewed attention around GLP-1 drugs has opened up conversations about obesity as a medical condition rather than a cosmetic concern.

Experts say that while such medications can be effective, they are not lifestyle replacements and must be prescribed carefully.

(Disclaimer: This article is for informational purposes only and does not substitute professional medical advice. Always consult a qualified healthcare provider before starting any medication.)